Publications and reports

Richardson S. C. W.* (2010) Tracking Intracellular Polymer Localisation Via Fluorescence Microscopy. In: Organelle-Specific Pharmaceutical Nanotechnology, Ed., Weissig V & D'Souza G. Artechhouse (in press).

Ferguson E., Richardson, S., Duncan, R. (2009) Studies on the Mechanism of Action of Dextrin-Phospholipase A2 and its Suitability for use in Combination Therapy. Molecular Pharmaceutics, 7(2) 210–321.

Richardson S.C.,* Pattrick N. G., Lavignac,N. Ferruti, P., Duncan, R. (2009) Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo, J. Controlled Release, 142: 78–88 (Cover story: Park K (editor in chief) (2010) Endocytic uptake and intracellular trafficking of poly(amidoamine)s J. Controlled Release, 142: 78–88.

John Spencer, Andrew P. Mendham, Arun K. Kotha, Simon C. W. Richardson, Elizabeth A. Hillard, Gerard Jaouen, Louise Male and Michael B. Hursthouse Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones, Dalton Trans., 2009, 918–921.

Richardson S. C. W.* Wallom K.-L,, Ferguson E. L., Deacon S. P. E., Davies M. W., Powell A. J., Piper R. C. and Duncan R. (2008) The Use of Fluorescence Microscopy to Define Polymer Conjugate Localisation to Late Endocytic Compartments in Fixed and Live Target Cells. J. Controlled Release, 127, 1–11.

Spencer, J., Patel, H.,Rathnam, R.P., Nazira, A. (2008) Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo(CO)6 & DBU, Tetrahedron, 64, 10195.

Spencer, J., Chowdhry, B.Z., Mallett, A.I.,Rahman, R.P.,Adatia, T.,Bashall, A.,Rominger, F. (2008) C-H activations on a 1H- 1,4-benzodiazepin-2(3H)-one template. Tetrahedron, 64, 6082.

Spencer, J., McDonald, I.M., Gaffen, J., Griffin, E., Harper, E.A., Linney, I.D., Roberts, S.P., Shaxted, M.E., Bashall, A., Adatia, T. (2008) Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template. Bioorg. Med. Chem., 16, 2974.

Getti, G., Cheke, R., Humber, D., Induction of apoptosis in host cells: a survival mechanism for Leishmania parasites? Parasitology 2008; 135(12):1391-9.

Getti, G., Durgadoss, P., Domínguez-Carmona, D., Martín-Quintal, Z., Peraza-Sánchez, S., Peña-Rodríguez, L., M. and Humber, D. Leishmanicidal activity of Yucatecan medicinal plants on Leishmania species responsible for cutaneous leishmaniasis. Journal of Parasitology. 2008 4:1.

Zhang Y., Zolov S. N., Chow C. Y., Richardson S. C., Piper R. C., Yang B., Westrick R. J., Meisler M. H., and Weisman L. S. (2007) A Defect in the Signaling Lipid Phosphatidylinositol 3,5-bisphosphate Causes Neurodegeneration in Mice. Proc. Nat. Acad. Sci. USA, 104(44), 17518–17523.

Getti, G.T., Aslam, S.N., Humber, D.P., Stevenson, P.C., Cheke, R.A. The effect of cicerfuran, an arylbenzofuran from Cicer bijugum, and  related benzofurans and stilbenes on Leishmania aethiopica, L. tropica and L. major. Planta Medica. 2006; 72(10):907–11.

Featured published articles

• Studies  on the Mechanism of Action of Dextrin−Phospholipase A2 and Its Suitability for Use in Combination Therapy. Dr Simon Richardson.
• Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine  kinase inhibitor sunitinib. Dr John Spencer.
• An  absolute structure template for a unique voltage-gated sodium channel binding site. Dr Mike Leach.