Dr Joshua Boateng

Dr Joshua Boateng obtained his Bachelor of Pharmacy degree from the Kwame Nkrumah University of Science and Technology in February 1999 (First Class Honours) and then pursued an MSc in pharmaceutical analysis programme at the University of Strathclyde under a DFID Commonwealth Scholarship, graduating in November 2000. He subsequently undertook PhD research in pharmaceutical sciences (drug delivery and formulation) under a Pfizer-sponsored project at the University of Strathclyde, graduating from 2001–05. He then took up a postdoctoral position at the Nottingham Trent University as part of a WADA-sponsored consortium on detecting gene doping in sports, using proteomic approaches (2005–07). Dr Boateng still maintains active research interests in all the above areas. He joined the School of Science at the University of Greenwich in August 2007 as Lecturer in Formulation Science.

Responsibilities within the university

Programme Leader

BSc Hons Forensic Science (2008-2012)

Course co-ordinator – undergraduate

Proteomics (BSc Biotechnology)

Course co-ordinator – postgraduate

Bioinformatics Module (MSc Biotechnology) 

Course participation

Introduction to Biotechnology
Bioinformatics
Intermediate Forensic Science Lab
Pharmaceuts
Pharmaceutical Product Development, Manufacture and Control
Applied Molecular Biology
Analytical Chemistry
Basic Chemistry for Life Sciences

MPhil/PhD students

Ms Farnoosh Kianfar: Novel polymer based formulations for delivering amorphous drugs via mucosal surfaces – university-funded (completed 2012)
Mr Isaac Ayensu: Development of novel formulations for mucosal delivery of protein-based drugs – Commonwealth Scholarship Grant (completed 2012)
Mr Mohammed Manirruzzaman: Development of Hot Melt Extrusion (HME) as a novel technique for the formulation of oral solid dosage forms – ORSAS Funded (completed 2012)
Harshavardhan Pawar: Novel wound healing drug delivery systems -ORSAS funded (expected completion July 2013).

Convenor

PhD, MPhil and MRES Research Seminars

Research interests

Dr Boateng belongs to the Pharmaceutical Science Research Cluster within the School of Science with researchers spanning pharmaceutical, analytical and material sciences. He works in an interdisciplinary range of research areas covering pharmaceutics (formulation and drug delivery), pharmaceutical analysis and proteomics.

Pharmaceutical formulation and drug delivery

• Preformulation studies
• Physical and chemical characterizations of drug delivery systems
• Formulation of mucosal (wounds, buccal, sublingual) drug delivery systems
• Films and freeze-dried polymeric systems for drug delivery
• Fast dissolving dosage forms including taste masking
• Controlled drug release studies.

Pharmaceutical and biotechnological analysis

• Quality of pharmaceutical formulations
• Fingerprinting of pharmaceutical biotech products using mass spectrometry.

Biomarker discovery

• Mass spectrometry (MALDI-TOF, LC-MS)
• Proteomics (protein and peptide biomarkers)
• Metabonomics (metabolic biomarkers).

Recent conference proceedings

1. Ayensu, I., Mitchell, J.C., and Boateng, J.S. 2012. Development of laminated thiolated chitosan-based lyophilised xerogels for potential buccal delivery of macromolecules. UK PHARMSCI Conference Proceedings.
2. Ayensu, I., Mitchell, J.C., and Boateng, J.S. 2012. In-vitro permeation studies of insulin using lamb buccal tissue and EpiOral^TM buccal tissue construct. UK PHARMSCI Conference Proceedings.
3. Pawar, H., Tetteh, J., and Boateng, J.S. 2012. Preparation and evaluation of solvent cast film dressings containing streptomycin and diclofenac for wound healing (AAPS).
4. Ayensu, I., Mitchell, J.C., and Boateng J.S. 2012. Evaluation of enzyme inhibitors on laminated thiolated chitosan xerogels for buccal delivery of insulin. (AAPS).
   

Recent publications

1. Kianfar, F., Ayensu, I., Boateng, J.S. 2013. Carrageenan and poloxamer based lyophilized polymeric matrix as a potential buccal drug delivery system. Drug Dev Ind Pharm, (In Press).
2. Boateng, J.S., Pawar, H.V., and Tetteh, J. 2013. Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing. Int J Pharm, 441(1-2):181-91.
3. Pawar, H.V., Tetteh, J., and Boateng, J.S. 2013. Preparation and characterization of novel wound healing film dressings loaded with streptomycin and diclofenac. Coll Surf B: Biointerf, 102, 102– 110.
4. Kianfar, F., Antonijevic, M., Chowdhry, B.Z., and Boateng, J.S. 2013. Lyophilized wafers comprising κ-carrageenan & pluronic acid for buccal drug delivery using model soluble and insoluble drugs. Coll Surf B: Biointerf, 103, 99– 106.
5. Maniruzzaman , M, Chowdhry, B.Z., Snowden, M.J., Boateng, J.S., and Douroumis D. 2012. A review of hot-melt extrusion (HME): Process technology to pharmaceutical products. ISRN Pharmaceutics, Article ID 436763, 9 pages, doi:10.5402/2012/436763.
6. Maniruzzaman, M., Rana, M.M., Boateng, J.S., Mitchell, J.C., and Douroumis, D. 2013. Dissolution enhancement of poorly water-soluble APIs processed by hot-melt extrusion (HME) using hydrophilic polymers. Drug Dev Ind Pharm 39(2), 218-27.
7. Pawar, H.V., Tetteh, J., and Boateng, J.S. 2012. Preparation and evaluation of streptomycin and diclofenac loaded mucoadhesive films for wound healing. Wound Repair Regen, 20 (2), A34.
8. Ayensu, I., and Boateng, J.S. 2012. Development and evaluation of lyophilized thiolated-chitosan wafers for buccal delivery of protein. J Sci Tech, 32, (2) 46-55 46
9. Ayensu, I., Mitchell, J.C., and Boateng, J.S. 2012. Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. Int J Biol Macromol, 50, 905-909.
10. Giovino, C., Ayensu, I., Tetteh, J., and Boateng J.S. 2012. Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): a potential approach for buccal delivery of macromolecules. Int J Pharm, 428 (1-2), 143-151.
11. Maniruzzaman, M., Boateng, J.S., Bonnefille, M., Aranyos, A., Mitchell, J.C., and Douroumis, D. 2012. Taste Masking of Paracetamol by Hot Melt Extrusion: an in vitro and in vivo evaluation. Eur J Pharm Biopharm. 80 (2): 433-442.
12. Ayensu, I., Mitchell, J.C., and Boateng, J.S. 2012. Preparation, evaluation and in-vitro characterisation of thiolated chitosan based lyophilized formulations for buccal mucosa delivery of proteins. Carb Polym, 89 935-941.
13. Ayensu, I., Mitchell, J.C., and Boateng, J.S. 2012. Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Coll Surf B: Biointerf, 91, 258– 265.
14. Pawar, H., Douroumis, D., and Boateng, J.S. 2012. Preparation and optimization of PMAA-Chitosan-PEG nanoparticles for oral drug delivery. Coll Surf B: Biointerf, 90, 102-108.
15. Kianfar, F., Chowdhry, B.Z., Antonijevic, M., and Boateng, J.S. 2012. Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs. Drug Dev Ind Pharm, 38(10):1207-20.
16. Boateng, J.S., Matthews, K.H., Auffret, A.D., Humphrey, M.J., Eccleston, G.M., and Stevens, H.N.E. 2012. Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent cast films containing an insoluble drug. Drug Dev Ind Pharm, Vol. 38, No. 1, 47-54.

A full list of Dr Joshua Boateng's conference proceedings and publications can be seen here.